BioC2024 brought the Bioconductor community together at the Van Andel Institute in Grand Rapids, Michigan, where we celebrated our shared work and explored the latest advancements in bioinformatics. Over 350 participants took part, with 116 attending in person and 240 joining virtually, allowing participants from regions as far away as Latin America, Africa, and Asia to be part of the event. This year’s conference also marked our first time in the Mid-West US, highlighting the expanding reach and diversity of our community.